The 49ers are gearing up for their game against the Buffalo Bills, but they'll be missing some key players. Let's take a look at who's out and who's questionable.

Defensive end Nick Bosa is on the sidelines with a hip and oblique injury. He last played against Seattle and has been rehabbing ever since. Trent Williams, the left tackle, is also out with an ankle injury. He's missed a few games this season due to injuries.

Cornerback Deommodore Lenoir hurt his knee in the game against Green Bay and hasn't practiced since. Left guard Aaron Banks is dealing with a concussion, and defensive tackle Jordan Elliott has the same issue. Linebacker Dre Greenlaw is just starting to practice after an Achilles injury, so he's not expected to play this week.

Now, let's talk about who might play. Quarterback Brock Purdy has a shoulder injury, but he was seen throwing during practice. Linebacker Demetrius Flannigan-Fowles has a knee injury, and wide receiver Chris Conley might be limited due to a knee issue. Defensive lineman Kevin Givens could return after missing some games, and cornerback Renardo Green is also working through a neck injury.

The 49ers have made some practice squad changes too. Sebastian Gutierrez was signed for a second time this season, and Cameron Erving was released.

Who's In, Who's Out: The 49ers' Injury Update

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