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Week 3 College Football: Bold Predictions and Surprise Picks

USAThursday, September 11, 2025
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College football's Week 3 is shaping up to be an exciting mix of upsets and dominant performances. Last week, underdog teams from smaller conferences pulled off some big wins, but this week, favorites might have a better chance.

Player Spotlights

Darian Mensah, Duke QB

  • Performance: Second-best passer in the country
  • Prediction: Over 400 yards and three touchdowns
  • Game: Duke vs. Tulane
  • Outcome: Road win for Duke

Cam Cook, Jacksonville State RB

  • Recent Stats: 270 yards on 46 carries
  • Game: Jacksonville State vs. Georgia Southern
  • Prediction: Over 200 yards and two touchdowns
  • Outcome: Road win for Jacksonville State

Bryant Wesco, Clemson WR

  • Situation: Filling in for injured top receiver Antonio Williams
  • Game: Clemson vs. Georgia Tech
  • Prediction: Eight catches for over 180 yards and two touchdowns

Big Games

Pittsburgh vs. West Virginia

  • Favorite: Pittsburgh
  • Key Player: QB Eli Holstein
  • Prediction: 10-point victory for Pittsburgh

No. 6 Georgia vs. No. 15 Tennessee

  • Favorite: Georgia
  • Series Dominance: Georgia has won eight straight
  • Key Player: RB Nate Frazier
  • Prediction: Over 100 yards and two touchdowns; Georgia wins by a touchdown

No. 18 South Florida vs. No. 5 Miami

  • Favorite: Miami
  • Key Player: QB Carson Beck
  • Prediction: Miami wins by 14 points

No. 16 Texas A&M vs. No. 8 Notre Dame

  • Favorite: Notre Dame
  • Key Factor: Notre Dame's running game
  • Prediction: Notre Dame wins by eight points

Florida vs. No. 3 LSU

  • Favorite: LSU
  • Key Player: QB Garrett Nussmeier
  • Prediction: LSU wins by four points

Upset Alert

Minnesota at Cal

  • Favorite: Cal
  • Key Players: Minnesota RBs Darius Taylor and Grant Washington
  • Prediction: Taylor rushes for over 100 yards and scores a touchdown; Cal secures a late stop to win

Reader Predictions

  • Ian: Four of five underdog teams will pull off upsets
  • Adam B.: Ohio will beat West Virginia
  • Josh V.: Kentucky will limit Ole Miss's passing yards
  • Brian M.: Jokes about Nick Saban's rental home policy

Last Week's Hits and Misses

Hits

  • Illinois picked off Darian Mensah and covered the spread
  • Iowa State beat Iowa again
  • Missouri covered the spread against Kansas
  • Oklahoma covered the spread at home

Misses

  • Florida's QB DJ Lagway didn't have the predicted game; Florida lost to South Florida
  • Arizona State almost pulled off a win against Mississippi State but came up short

Week 3 promises more excitement, with underdogs looking to pull off upsets and favorites aiming to dominate.

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