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Week 3 College Football: Bold Predictions and Surprise Picks
USAThursday, September 11, 2025
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College football's Week 3 is shaping up to be an exciting mix of upsets and dominant performances. Last week, underdog teams from smaller conferences pulled off some big wins, but this week, favorites might have a better chance.
Player Spotlights
Darian Mensah, Duke QB
- Performance: Second-best passer in the country
- Prediction: Over 400 yards and three touchdowns
- Game: Duke vs. Tulane
- Outcome: Road win for Duke
Cam Cook, Jacksonville State RB
- Recent Stats: 270 yards on 46 carries
- Game: Jacksonville State vs. Georgia Southern
- Prediction: Over 200 yards and two touchdowns
- Outcome: Road win for Jacksonville State
Bryant Wesco, Clemson WR
- Situation: Filling in for injured top receiver Antonio Williams
- Game: Clemson vs. Georgia Tech
- Prediction: Eight catches for over 180 yards and two touchdowns
Big Games
Pittsburgh vs. West Virginia
- Favorite: Pittsburgh
- Key Player: QB Eli Holstein
- Prediction: 10-point victory for Pittsburgh
No. 6 Georgia vs. No. 15 Tennessee
- Favorite: Georgia
- Series Dominance: Georgia has won eight straight
- Key Player: RB Nate Frazier
- Prediction: Over 100 yards and two touchdowns; Georgia wins by a touchdown
No. 18 South Florida vs. No. 5 Miami
- Favorite: Miami
- Key Player: QB Carson Beck
- Prediction: Miami wins by 14 points
No. 16 Texas A&M vs. No. 8 Notre Dame
- Favorite: Notre Dame
- Key Factor: Notre Dame's running game
- Prediction: Notre Dame wins by eight points
Florida vs. No. 3 LSU
- Favorite: LSU
- Key Player: QB Garrett Nussmeier
- Prediction: LSU wins by four points
Upset Alert
Minnesota at Cal
- Favorite: Cal
- Key Players: Minnesota RBs Darius Taylor and Grant Washington
- Prediction: Taylor rushes for over 100 yards and scores a touchdown; Cal secures a late stop to win
Reader Predictions
- Ian: Four of five underdog teams will pull off upsets
- Adam B.: Ohio will beat West Virginia
- Josh V.: Kentucky will limit Ole Miss's passing yards
- Brian M.: Jokes about Nick Saban's rental home policy
Last Week's Hits and Misses
Hits
- Illinois picked off Darian Mensah and covered the spread
- Iowa State beat Iowa again
- Missouri covered the spread against Kansas
- Oklahoma covered the spread at home
Misses
- Florida's QB DJ Lagway didn't have the predicted game; Florida lost to South Florida
- Arizona State almost pulled off a win against Mississippi State but came up short
Week 3 promises more excitement, with underdogs looking to pull off upsets and favorites aiming to dominate.
notre damemississippi statearizona statesouth floridaoklahomakansasmissouriiowa stateillinoisoregonkentuckywest virginiaohiominnesotastexasmiamigeorgiatennesseepittsburghjacksonville statedj lagwayadam wmark llarry vsean shannonnick sabanbrian mjosh vadam bgrant washingtondarius taylorcal calgarrett nussmeiercarson becknate fraziereli holsteinbryantantonio williamscam cook
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