A deadly disease called malignant catarrhal fever (MCF) is a big problem for cattle farmers in East Africa. This disease is caused by a virus from wildebeest. Scientists have created a vaccine to help protect cattle. The study we are talking about is the first time this vaccine was used in the field with locally-owned cattle in Tanzania. They vaccinated 1634 cattle with two doses and later gave a booster to 385 of them. The goal was to see how well the vaccine works and if it affects different groups of cattle like old or young, males or females, and cattle in different health conditions. Researchers also compared single and double booster shots to see which is better. The results showed that the vaccine worked really well. Only 11 out of 1634 cattle got sick after the first shots. The vaccine clearly improved the immune system of the cattle. They found that older cattle, pregnant ones, and those in good health responded better. Even though antibody levels went down after 11 months, they stayed high enough that a single booster shot was enough to give a strong immune response. This study is great news for farmers, as it shows the vaccine can be used to protect their cattle. It could also help make farming more sustainable in the long run.

Vaccinating Cattle in Tanzania: A Battle Against Malignant Catarrhal Fever

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