Did you know that COVID-19, the disease that has sadly caused many deaths globally, could be a lot better managed with early detection? Doctors could greatly benefit from identifying individuals who face a high risk of facing a severe form of the disease.

        So, what if a simple urine test could help pick up signs of danger?  That's the focus of a recent investigation by researchers who were intrigued by a chemical signaling distress in our bodies.

        Going into the lab, they focused on the concept of a molecule named 8-hydroxy-2'-deoxyguanosine, or 8-OHdG for short. 8-OHdG is crucial because it's linked to damage in our cells. This molecule can spring up when your body is under oxidative stress, a highly reactive state that can cause harm.

        COVID-19 is known to cause this type of stress. But here's where things get interesting. This molecule, in its way a cellular "signal" was seen especially in patients with stage 4 COVID-19 and cancer. The researchers were wondering if the molecules were higher in those more prone to sever COVID-19 complications.

        What did they do to test it? Scientists carefully tracked 8-OHdG levels in urine samples using a method called dispersive liquid-liquid microextraction (DLLME).

        DLLME The 8OHdG could be tracked using gas chromatography-mass spectrometry, or GC-MS.

        Use of DLLME in tracking 8-OHdG marked a milestone for a first time tracking!

        Researchers found that urine tests showed markedly higher 8-OHdG levels in COVID-19 patients, including those with cancer, compared to healthy individuals. This suggests oxidation stress has a broader effect in COVID-19 complications.

        One thing to consider is if your system is highly stressed, it might warrant a more cautious approach.

    The science of early intervention holds immense promise for better clinical outcomes. But remember, more data is needed to substantiate the apparent link. The advantages of DLLEM, thanks to its efficiency and cost-effectiveness. The required parameters were tested and compared to various concentrations it proved to be at par

        In summary,  This discovery

        might help us see use of urine tests for COVID-19 better in the clinical care of patients with COVID-19. For it has revealed many key points like  these biochemical signals can increase the odds for early intervention of the disease.

   Now, a criticl think would be is this a worthy screening?  what mechanism justifies this pathway.

        Covid 19 can burden immunity via oxidative stress

        For starters, this paper asks will 8-OHdG help us manage COVID-19 patients? What does it uncover?

        Now, think about what the bigger picture: oxidastive stress and disease, In order understand the disease.

        Here is one thing to be aware of:  Take it simple as understanding 8-OHdG use by expertye instead of eyesight or nobel rhetore after wins the novel prize.

        With advancement in medical science, hope is on everyone faces.  new instruments and tools reveal risks at a first glance.

Uncovering COVID-19 Risks through Urine Tests: Scientists Spot a Stress Signal

Actions