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The Ozempic Dilemma: Why Stopping Too Soon Can Backfire
Oxford, UKThursday, January 8, 2026
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Obesity drugs like Ozempic and Wegovy are revolutionizing weight loss, but quitting them can lead to rapid weight regain.
The Problem with Stopping Medication
- Research from the University of Oxford found that people who stop GLP-1 drugs often gain back almost a pound every month.
- This is worse than those who lose weight through lifestyle changes only.
The Study's Findings
- Data from nearly 10,000 people showed that those who stopped newer GLP-1 drugs like semaglutide and tirzepatide regained weight even faster.
- They put back 1.8 pounds a month.
- At this rate, they return to their starting weight in just over a year.
- This is much quicker than people who stop lifestyle programs, who regain weight at a slower pace.
The Complexity of Obesity Treatment
- Obesity is a long-term condition.
- Stopping medication can lead to weight regain, even with GLP-1 drugs.
- The study highlights the need for a comprehensive approach to weight management.
- Many people may need to stay on these meds long-term.
- But high costs and side effects make this tough for many.
The Need for Better Strategies
- The findings show that obesity treatment is complex.
- Quitting GLP-1 drugs can lead to rapid weight regain.
- This underscores the need for better long-term strategies.
- People need support to manage their weight effectively.
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