Fibromyalgia is a mysterious disease, with a lot of people not knowing what is going on in their heads and bodies. Doctors are constantly searching for biomarkers to understand it better. We looked into two Biomarkers, called "miR-217" and "miR-532", and its presence in blood in order to find a link this disease. 80 people were part of this study. It included 40 people who have fibromyalgia  (These people were 12 males, and 28 females) and 40 people who never had fibromyalgia (These people were 10 males, and 30 females). It is known that fibromyalgia can happen to anyone but it is observed more often in females.

        People are constantly searching for a way to detect fibromyalgia earlier. Several avenues have been explored, including mi-RNAs screening. Mira-RNAs are the gold standard in medicine for diagnosing and detecting. The study found that the expression of miR-217 and miR-532 of fibromyalgia sufferers decreased dramatically when compared to the control group. The differences were significant, with the following results: the median expression of miR-217 in fibromyalgia patients was 0. 1359, compared to 0. 683 in the control group.  miR-532 expression showed similar results, with a median of 0. 2199 in fibromyalgia patients compared to 0. 721 in the control group.

        Fibromyalgia is shown to have an association between liver enzymes and biomarkers. These findings were also present in this study as well. The study also found that there was a negative correlation between the two biomarkers and liver enzymes, specifically AST. That means If AST goes up then these biomarkers will go down. This could be an important step towards creating better diagnostic pathways for fibromyalgia. However, all findings should be taken with a grain of salt. More studies must check if this is consistent in other patients' samples.

        While these findings are intriguing and promising, it is important to remember that fibromyalgia is a complex and multifactorial disease, with many contributing factors. With more studies and data, more effective treatments or diagnostic can be made. This research adds to the growing body of research that supports the use of biomarkers as a tool for detecting diseases. Maybe, it is loved to hope with all our findings, maybe 1 day we can get a fibromyalgia test from our blood.

Small Clues in Blood: Who Knows Hope What Blood Can Do

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