How a Tiny Gene Change Can Affect Your Pet's Health

The Role of MDR1

Cats and dogs possess a vital protein known as MDR1, which functions like a bouncer, regulating the entry of drugs into the brain. Its primary role is to block harmful drugs, such as ivermectin, preventing toxic reactions.

The Danger of MDR1 Mutations

In some pets, a minor genetic mutation in the MDR1 gene can disable the protein. This failure allows harmful drugs to enter the brain, leading to serious side effects.

Research Findings

A recent study analyzed 800 cats in Germany and discovered that 0.625% carried the faulty MDR1 gene. Though rare, this mutation remains a concern for pet owners.

Scientists tested the effectiveness of both normal and faulty MDR1 proteins using rhodamine 123, a glowing substance. The normal MDR1 proteins successfully expelled the substance, while the faulty proteins failed.

Drug Interference with MDR1

The study also revealed that common medications, such as verapamil and certain antiparasitic drugs, can interfere with MDR1 function. This indicates that MDR1 plays a broader role beyond just blocking ivermectin.

What Pet Owners Should Know

It is crucial to determine if your pet has the MDR1 mutation. If they do, extra caution is needed when administering certain medications. Always consult your vet before using any new treatments.