Type 2 diabetes mellitus is a massive global issue. By 2045, experts predict that over 629 million people will be dealing with it. This condition seriously raises the risk of heart disease and other serious health problems. Even if blood sugar levels return to normal, the damage from high blood sugar can last. This is because high blood sugar leaves a lasting mark on the body's cells and molecules, a concept known as "metabolic memory. "

Good news is that putting type 2 diabetes into remission is becoming more realistic. Achieving remission can lead to fewer health issues, a better life, and keeping the body's insulin-producing cells working well. One of the most effective ways to achieve this is through metabolic surgery. This surgery causes big changes in the body's hormones, like boosting levels of a substance called GLP-1. It also improves how the body handles bile acids and reduces harmful fat in the liver and pancreas. All of these changes help the body use and produce insulin better.

But surgery is not the only way. Big lifestyle changes and certain medications can also help, especially if started early. These include drugs that mimic natural hormones like GLP-1 and new combinations that target multiple pathways. Who benefits most from these treatments? Generally, younger people, those who have had diabetes for a shorter time, and those with better initial blood sugar control and fewer medications. Losing a significant amount of weight also plays a big role.

New tools are being developed to help predict who will benefit most from these treatments. These include scoring systems, advanced computer models, and specific biomarkers. These tools can help doctors personalize treatment plans and increase the chances of successful remission. It is crucial to start treatment early and use a team approach that includes different healthcare professionals. This way, the best results can be achieved, and overall metabolic health can be improved.

Curing Type 2 Diabetes: Can It Really Happen?

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